Natural product Stat3 Inhibitors

Case ID: 00950


A series of new products isolated from a medicinal plant, Vernonia cinerea, controlled human cancer growth by blocking the abnormal functions of the transcription factor, STAT3 signaling. The natural product molecules showed inhibitory effects against growth of triple negative breast cancer which are non-responsive to current hormone therapies and have an up-regulated interleukin-6/STAT3 signaling axis. Treatment of human breast cancer and glioma cells growing in culture lead to inhibition of cell growth and survival.



Stat3 inhibitor of growth of cancer cells with activated Stat3.



These compounds inhibit a specific and critical molecular target in cancer cells - Stat3.

Patent Information:
Leng Chee Chang
James Turkson
Supakit Wongwiwatthananukit
Ui Joung Youn
Dianqing Sun

For information, contact:
Ann Park
Technology Licensing Associate
University of Hawaii
(808) 956-9929

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