Search Results - Healthcare

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Inhibitors of soluble epoxide hydrolase and p38 kinase as Alzheimer's therapeutics
A Potent Neuroprotective Mechanism for Alzheimer’s Disease Case ID:18/0025BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disorder. Neuroinflammation is a prevalent pathogenic stress leading to neuronal death in AD. Targeting neuroinflammation to keep neurons alive is an attractive strategy for AD therapy. 1-Trif...
Published: 4/23/2019   |   Inventor(s): Qing Xiao Li, Zhibin (Ben) Liang
Category(s): Therapeutic, Healthcare
Titanocene-Gold Derivatives as Chemotherapeutics for Renal Cancer
Gold complexes have shown promise in cancer chemotherapy, with several compounds having overcome cisplatin resistance of specific cancer cells, furthering their appeal. Early-transition metal complexes, particularly titanocene-based complexes, are another class of compounds being explored for cancer chemotherapy. Recently novel metallodrugs have be...
Published: 7/20/2018   |   Inventor(s): Joe Ramos, Maria Contel, Jacob Fernandez-Gallardo, Benelita Elie
Category(s): Healthcare
Smart Actuator for Medical Device Locating and Positioning
The invention involves the use of advanced materials and actuators to assist in the positioning of medical devices inserted using transcatheter approaches. The actuator device utilizes shape memory components that are able to achieve movements in multiple directions and resume their original shape in response to selective actuation. Attachment of t...
Published: 9/25/2017   |   Inventor(s): Bardia Konh
Category(s): Devices, Engineering, Healthcare, Materials Science
Plants Expressing the Miraculin Protein, a Sweetener
Researchers at UH-Hilo have developed a method for expressing miraculin, a flavor-altering protein, in lettuce. The protein is found naturally in berries of the miracle berry plant, Synsepalum dulcificum, and binds to sweet receptors on the tongue, temporarily producing a sweet taste for sour foods. The genetically engineered lettuce accumulates f...
Published: 7/26/2017   |   Inventor(s): Michael Shintaku, Lukas Kambic
Keywords(s): Agriculture:Transgenics, Healthcare
Category(s): Agriculture/Aquaculture, Healthcare
Selective Inhibitors of GSK3-beta
Technology Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase that is being investigated clinically for a variety of therapeutic applications including CNS disorders, metabolic disorders and in dental health. Centrally, GSK3 is primarily responsible for aberrant phosphorylation of tau leading to pathologic...
Published: 1/31/2017   |   Inventor(s): Qing Xiao Li, Zhibin (Ben) Liang
Keywords(s): Healthcare:Alzheimer’s Disease, Healthcare:Metabolic Diseases, Healthcare:Neurological Disorders, Healthcare:Oncology, Healthcare:Therapeutic, Therapeutic
Category(s): Chemistry, Healthcare, Therapeutic
Method for Reducing or Preventing Immunogenic Response
This invention involves the use of humanized cobra venom factor (hCVF) to prevent or reduce immunogenicity and other unwanted immunological reactions as a consequence of administering biologics therapy. In many therapeutic situations, biologics agents may induce unwanted immune response that can cause clinical challenges and ineffective treatment. ...
Published: 6/16/2015   |   Inventor(s): Carl-Wilhelm Vogel, Paul Finnegan, Julie Rayes, Sebastien Lacroix-Desmazes
Category(s): Healthcare
anti-HMGB1 antibody for mesothelioma
In the US, asbestos causes approximately 2,000 - 3,000 malignant mesothelioma deaths per year, and it contributes to an even larger number of lung carcinomas. The latency from time of exposure to tumor development potentially allows time for intervention to block the mechanism(s) that trigger asbestos-induced carcinogenesis. This invention proposes...
Published: 5/29/2015   |   Inventor(s): Haining Yang, Michele Carbone, Marco Bianchi
Category(s): Healthcare, Therapeutic
Mesothelioma Biomarker
Malignant mesothelioma, which is associated with asbestos or erionite exposure, is an aggressive and lethal cancer of the mesothelium, the protective lining that covers many internal organs and is most commonly found in the lungs. The inventors have discovered that misregulation of a protein called High Mobility Group Box 1 (HMGB1) is linked to mes...
Published: 5/29/2015   |   Inventor(s): Haining Yang, Michele Carbone, Harvey Pass
Keywords(s): Diagnostic:Marker, Healthcare:Diagnostic Tool, Healthcare:Oncology, Screening:Detection
Category(s): Healthcare, Diagnostic, Diagnostic, Therapeutic
Natural product Stat3 Inhibitors
A series of new products isolated from a medicinal plant, Vernonia cinerea, controlled human cancer growth by blocking the abnormal functions of the transcription factor, STAT3 signaling. The natural product molecules showed inhibitory effects against growth of triple negative breast cancer which are non-responsive to current hormone therapies and ...
Published: 5/27/2015   |   Inventor(s): Leng Chee Chang, James Turkson, Supakit Wongwiwatthananukit, Ui Joung Youn, Dianqing Sun
Category(s): Healthcare
Panel of lincRNAs as Robust Pan-Cancer Diagnostic and Prognostic Biomarkers
Published: 5/26/2015   |   Inventor(s): Lana Garmire, Travers Ching
Category(s): Healthcare
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