Search Results - healthcare%3aoncology

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Technology Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase that is being investigated clinically for a variety of therapeutic applications including CNS disorders, metabolic disorders and in dental health. Centrally, GSK3 is primarily responsible for aberrant phosphorylation of tau leading to pathological...

Published: 10/6/2023 | Inventor(s): Qing Xiao Li, Zhibin (Ben) Liang

Keywords(s): Healthcare:Alzheimer’s Disease, Healthcare:Metabolic Diseases, Healthcare:Neurological Disorders, Healthcare:Oncology, Healthcare:Therapeutic, Therapeutic

Category(s): Chemistry, Healthcare, Therapeutic

Mesothelioma Biomarker - High Mobility Group Box 1 (HMGB1) protein as a novel, sensitive biomarker for detecting asbestos exposure and mesothelioma

Malignant mesothelioma, associated with asbestos or erionite exposure, is an aggressive and lethal cancer of the mesothelium, the protective lining that covers many internal organs, and is most commonly found in the pleura (outer lining of the lungs). The inventors discovered that misregulation of a protein called High Mobility Group Box 1 (HMGB1) is...

Published: 2/29/2024 | Inventor(s): Haining Yang, Michele Carbone, Harvey Pass

Keywords(s): Diagnostic:Marker, Healthcare:Diagnostic Tool, Healthcare:Oncology, Screening:Detection

Category(s): Healthcare, Diagnostic, Diagnostic, Therapeutic

A novel Stat3 inhibitor that suppresses growth, viability, survival and migration of human breast and glioma cells in vitro

Researchers have discovered a new chemical compound that blocks the cancer causing biological molecule called Stat3, and by doing so controls growth and existence of human cancer cells. The compound strongly inhibits the activated form of Stat3, and consequently attenuates Stat3 functions in cancer cells. Accordingly, treatment of human breast cancer...

Published: 8/3/2022 | Inventor(s): James Turkson, Patrick Gunning, Sina Haftchenary

Keywords(s): Healthcare:Oncology

Category(s): Healthcare, Therapeutic