Search Results - james+turkson

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A series of new products isolated from a medicinal plant, Vernonia cinerea, controlled human cancer growth by blocking the abnormal functions of the transcription factor, STAT3 signaling. The natural product molecules showed inhibitory effects against growth of triple negative breast cancer which are non-responsive to current hormone therapies and have...

Published: 11/22/2021 | Inventor(s): Leng Chee Chang, James Turkson, Supakit Wongwiwatthananukit, Ui Joung Youn, Dianqing Sun

Keywords(s):

Category(s): Healthcare

Natural product inhibitors of Stat3 and NF-kappaB

Physalis peruviana and poha berry fruit have been found to control human cancer growth by blocking the abnormal functions of Stat3 and NF-kappaB signaling pathways. Inhibitory effects were observed in human glioma, bladder carcinoma, and breast cancer cells in vitro. ApplicationsGrowth inhibition in cancers with activated Stat3 and NF-kappaB signaling...

Published: 6/27/2018 | Inventor(s): Leng Chee Chang, John Pezzuto, James Turkson, Mayuramas Sang-Ngern

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Category(s): Healthcare, Therapeutic

A novel Stat3 inhibitor that suppresses growth, viability, survival and migration of human breast and glioma cells in vitro

Researchers have discovered a new chemical compound that blocks the cancer causing biological molecule called Stat3, and by doing so controls growth and existence of human cancer cells. The compound strongly inhibits the activated form of Stat3, and consequently attenuates Stat3 functions in cancer cells. Accordingly, treatment of human breast cancer...

Published: 8/3/2022 | Inventor(s): James Turkson, Patrick Gunning, Sina Haftchenary

Keywords(s): Healthcare:Oncology

Category(s): Healthcare, Therapeutic