Search Results - therapeutic

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An economical method of producing recombinant Arthromyces ramosus peroxidase with high yield, purity, stability and robustness Background Peroxidases are valuable heme-containing enzymes that catalyze the oxidation of various phenolic and non-phenolic substrates by hydrogen peroxide. They have important applications in biomedicine, agriculture,...

Published: 3/16/2023 | Inventor(s): Qing Xiao Li, Yuqun Yao

Keywords(s):

Category(s): Agriculture/Aquaculture, Environmental Sciences, Therapeutic

Application of Neuroprotective Beta Amyloid Core Peptides and Peptidomimetic Derivatives to the Treatment of Alzheimer's Disease

Despite a notable role for amyloid and amyloid plaques in Alzheimer's disease, treatments aimed at lowering the levels of beta amyloid or disrupting amyloid plaques have had little or no impact on the disease. Using a novel approach, a core hexapeptide fragment derived from beta amyloid has been shown to be protective at the synaptic, cellular and behavioral...

Published: 7/19/2022 | Inventor(s): Robert Nichols, Kelly Forest, Victor Hruby

Keywords(s): Healthcare:Alzheimer’s Disease, Healthcare:Neurological Disorders, Research Tool:Cell Culture & Media, Research Tool:Cell Line, Screening:Cellular Assay, Therapeutic:Disease Model, Therapeutic:Drug Delivery, Therapeutic:Peptides

Category(s): Therapeutic

Selective Inhibitors of GSK3-beta

Technology Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase that is being investigated clinically for a variety of therapeutic applications including CNS disorders, metabolic disorders and in dental health. Centrally, GSK3 is primarily responsible for aberrant phosphorylation of tau leading to pathological...

Published: 10/6/2023 | Inventor(s): Qing Xiao Li, Zhibin (Ben) Liang

Keywords(s): Healthcare:Alzheimer’s Disease, Healthcare:Metabolic Diseases, Healthcare:Neurological Disorders, Healthcare:Oncology, Healthcare:Therapeutic, Therapeutic

Category(s): Chemistry, Healthcare, Therapeutic

anti-HMGB1 antibody for mesothelioma

In the US, asbestos causes approximately 2,000 - 3,000 malignant mesothelioma deaths per year, and it contributes to an even larger number of lung carcinomas. The latency from time of exposure to tumor development potentially allows time for intervention to block the mechanism(s) that trigger asbestos-induced carcinogenesis. This invention proposes...

Published: 11/19/2021 | Inventor(s): Haining Yang, Michele Carbone, Marco Bianchi

Keywords(s):

Category(s): Healthcare, Therapeutic

Mesothelioma Biomarker - High Mobility Group Box 1 (HMGB1) protein as a novel, sensitive biomarker for detecting asbestos exposure and mesothelioma

Malignant mesothelioma, associated with asbestos or erionite exposure, is an aggressive and lethal cancer of the mesothelium, the protective lining that covers many internal organs, and is most commonly found in the pleura (outer lining of the lungs). The inventors discovered that misregulation of a protein called High Mobility Group Box 1 (HMGB1) is...

Published: 2/29/2024 | Inventor(s): Haining Yang, Michele Carbone, Harvey Pass

Keywords(s): Diagnostic:Marker, Healthcare:Diagnostic Tool, Healthcare:Oncology, Screening:Detection

Category(s): Healthcare, Diagnostic, Diagnostic, Therapeutic

Natural product inhibitors of Stat3 and NF-kappaB

Physalis peruviana and poha berry fruit have been found to control human cancer growth by blocking the abnormal functions of Stat3 and NF-kappaB signaling pathways. Inhibitory effects were observed in human glioma, bladder carcinoma, and breast cancer cells in vitro. ApplicationsGrowth inhibition in cancers with activated Stat3 and NF-kappaB signaling...

Published: 6/27/2018 | Inventor(s): Leng Chee Chang, John Pezzuto, James Turkson, Mayuramas Sang-Ngern

Keywords(s):

Category(s): Healthcare, Therapeutic

A novel Stat3 inhibitor that suppresses growth, viability, survival and migration of human breast and glioma cells in vitro

Researchers have discovered a new chemical compound that blocks the cancer causing biological molecule called Stat3, and by doing so controls growth and existence of human cancer cells. The compound strongly inhibits the activated form of Stat3, and consequently attenuates Stat3 functions in cancer cells. Accordingly, treatment of human breast cancer...

Published: 8/3/2022 | Inventor(s): James Turkson, Patrick Gunning, Sina Haftchenary

Keywords(s): Healthcare:Oncology

Category(s): Healthcare, Therapeutic