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MRI-compatible Robot Using Actively Controlled Steerable Needles

MRI-compatible robot enables teleoperative, image-guided needle insertion and manipulation that can move in a curvilinear path Background Conventional medical imaging modalities such as ultrasound and CT for visualization and tip tracking of needles in needle-based procedures are usually challenging. MRI provides superior visualization and...

Published: 5/1/2024 | Inventor(s): Bardia Konh, Blayton Padasdao, Samuel Lafreniere

Keywords(s):

Category(s): Devices, Healthcare

Titanocene-Gold Derivatives as Chemotherapeutics for Renal Cancer

Gold complexes have shown promise in cancer chemotherapy, with several compounds having overcome cisplatin resistance of specific cancer cells, furthering their appeal. Early-transition metal complexes, particularly titanocene-based complexes, are another class of compounds being explored for cancer chemotherapy. Recently novel metallodrugs have been...

Published: 10/6/2023 | Inventor(s): Joe Ramos, Maria Contel, Jacob Fernandez-Gallardo, Benelita Elie

Keywords(s):

Category(s): Healthcare

Smart Actuator for Medical Device Locating and Positioning

The invention involves the use of advanced materials and actuators to assist in the positioning of medical devices inserted using transcatheter approaches. The actuator device utilizes shape memory components that are able to achieve movements in multiple directions and resume their original shape in response to selective actuation. Attachment of the...

Published: 10/6/2023 | Inventor(s): Bardia Konh

Keywords(s):

Category(s): Devices, Engineering, Healthcare, Materials Science

Plants Expressing the Miraculin Protein, a Sweetener

Researchers at UH-Hilo have developed a method for expressing miraculin, a flavor-altering protein, in lettuce. The protein is found naturally in berries of the miracle berry plant, Synsepalum dulcificum, and binds to sweet receptors on the tongue, temporarily producing a sweet taste for sour foods. The genetically engineered lettuce accumulates functional...

Published: 7/20/2022 | Inventor(s): Michael Shintaku, Lukas Kambic

Keywords(s): Agriculture:Transgenics, Healthcare

Category(s): Agriculture/Aquaculture, Healthcare

Selective Inhibitors of GSK3-beta

Technology Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase that is being investigated clinically for a variety of therapeutic applications including CNS disorders, metabolic disorders and in dental health. Centrally, GSK3 is primarily responsible for aberrant phosphorylation of tau leading to pathological...

Published: 10/6/2023 | Inventor(s): Qing Xiao Li, Zhibin (Ben) Liang

Keywords(s): Healthcare:Alzheimer’s Disease, Healthcare:Metabolic Diseases, Healthcare:Neurological Disorders, Healthcare:Oncology, Healthcare:Therapeutic, Therapeutic

Category(s): Chemistry, Healthcare, Therapeutic

Novel Human C3 Derivatives for Therapeutic Complement Depletion - Complement depletion as a novel therapeutic approach, with applications in treating diseases with complement pathology

The complement system is part of the immune system and is important in both innate and adaptive immunity. However, the complement system can also be a pathogenetic factor in many diseases including, rheumatoid arthritis, reperfusion injury, myasthenia gravis, and more. Complement has also been shown to be important for the development of antibodies...

Published: 10/6/2023 | Inventor(s): Carl-Wilhelm Vogel, Paul Finnegan, Julie Rayes, Sebastien Lacroix-Desmazes

Keywords(s):

Category(s): Healthcare

anti-HMGB1 antibody for mesothelioma

In the US, asbestos causes approximately 2,000 - 3,000 malignant mesothelioma deaths per year, and it contributes to an even larger number of lung carcinomas. The latency from time of exposure to tumor development potentially allows time for intervention to block the mechanism(s) that trigger asbestos-induced carcinogenesis. This invention proposes...

Published: 11/19/2021 | Inventor(s): Haining Yang, Michele Carbone, Marco Bianchi

Keywords(s):

Category(s): Healthcare, Therapeutic

Mesothelioma Biomarker - High Mobility Group Box 1 (HMGB1) protein as a novel, sensitive biomarker for detecting asbestos exposure and mesothelioma

Malignant mesothelioma, associated with asbestos or erionite exposure, is an aggressive and lethal cancer of the mesothelium, the protective lining that covers many internal organs, and is most commonly found in the pleura (outer lining of the lungs). The inventors discovered that misregulation of a protein called High Mobility Group Box 1 (HMGB1) is...

Published: 11/19/2024 | Inventor(s): Haining Yang, Michele Carbone, Harvey Pass

Keywords(s): Diagnostic:Marker, Healthcare:Diagnostic Tool, Healthcare:Oncology, Screening:Detection

Category(s): Healthcare, Diagnostic, Diagnostic, Therapeutic

Natural product Stat3 Inhibitors

A series of new products isolated from a medicinal plant, Vernonia cinerea, controlled human cancer growth by blocking the abnormal functions of the transcription factor, STAT3 signaling. The natural product molecules showed inhibitory effects against growth of triple negative breast cancer which are non-responsive to current hormone therapies and have...

Published: 11/22/2021 | Inventor(s): Leng Chee Chang, James Turkson, Supakit Wongwiwatthananukit, Ui Joung Youn, Dianqing Sun

Keywords(s):

Category(s): Healthcare

Natural product inhibitors of Stat3 and NF-kappaB

Physalis peruviana and poha berry fruit have been found to control human cancer growth by blocking the abnormal functions of Stat3 and NF-kappaB signaling pathways. Inhibitory effects were observed in human glioma, bladder carcinoma, and breast cancer cells in vitro. ApplicationsGrowth inhibition in cancers with activated Stat3 and NF-kappaB signaling...

Published: 6/27/2018 | Inventor(s): Leng Chee Chang, John Pezzuto, James Turkson, Mayuramas Sang-Ngern

Keywords(s):

Category(s): Healthcare, Therapeutic

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