Search Results - healthcare%3aneurological+disorders

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Application of Neuroprotective Beta Amyloid Core Peptides and Peptidomimetic Derivatives to the Treatment of Alzheimer's Disease

Despite a notable role for amyloid and amyloid plaques in Alzheimer's disease, treatments aimed at lowering the levels of beta amyloid or disrupting amyloid plaques have had little or no impact on the disease. Using a novel approach, a core hexapeptide fragment derived from beta amyloid has been shown to be protective at the synaptic, cellular and behavioral...

Published: 7/19/2022 | Inventor(s): Robert Nichols, Kelly Forest, Victor Hruby

Keywords(s): Healthcare:Alzheimer’s Disease, Healthcare:Neurological Disorders, Research Tool:Cell Culture & Media, Research Tool:Cell Line, Screening:Cellular Assay, Therapeutic:Disease Model, Therapeutic:Drug Delivery, Therapeutic:Peptides

Category(s): Therapeutic

Selective Inhibitors of GSK3-beta

Technology Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase that is being investigated clinically for a variety of therapeutic applications including CNS disorders, metabolic disorders and in dental health. Centrally, GSK3 is primarily responsible for aberrant phosphorylation of tau leading to pathological...

Published: 10/6/2023 | Inventor(s): Qing Xiao Li, Zhibin (Ben) Liang

Keywords(s): Healthcare:Alzheimer’s Disease, Healthcare:Metabolic Diseases, Healthcare:Neurological Disorders, Healthcare:Oncology, Healthcare:Therapeutic, Therapeutic

Category(s): Chemistry, Healthcare, Therapeutic