Search Results - Therapeutic

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Application of Neuroprotective Beta Amyloid Core Peptides and Peptidomimetic Derivatives to the Treatment of Alzheimer's Disease
Despite a notable role for amyloid and amyloid plaques in Alzheimer's disease, treatments aimed at lowering the levels of beta amyloid or disrupting amyloid plaques have had little or no impact on the disease. Using a novel approach, a core hexapeptide fragment derived from beta amyloid has been shown to be protective at the synaptic, cellular and ...
Published: 10/5/2017   |   Inventor(s): Robert Nichols, Kelly Forest, Victor Hruby
Keywords(s): Healthcare:Alzheimer’s Disease, Healthcare:Neurological Disorders, Research Tool:Cell Culture & Media, Research Tool:Cell Line, Screening:Cellular Assay, Therapeutic:Disease Model, Therapeutic:Drug Delivery, Therapeutic:Peptides
Category(s): Therapeutic
Selective Inhibitors of GSK3-beta
Technology Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase that is being investigated clinically for a variety of therapeutic applications including CNS disorders, metabolic disorders and in dental health. Centrally, GSK3 is primarily responsible for aberrant phosphorylation of tau leading to pathologic...
Published: 1/31/2017   |   Inventor(s): Qing Xiao Li, Zhibin Liang
Keywords(s): Healthcare:Alzheimer’s Disease, Healthcare:Metabolic Diseases, Healthcare:Neurological Disorders, Healthcare:Oncology, Healthcare:Therapeutic, Therapeutic
Category(s): Chemistry, Healthcare, Therapeutic
C-Glycosylflavones for prevention and treatment of Alzheimer's disease
The available technology is a method of combating the most common brain disorder worldwide--Alzheimer’s disease. The technology is an extract of corn silk, a product that little research to date has been conducted on. More specifically, this specific corn silk extract containing C-glycosylflavones inhibits a specific kinase attributing to Alz...
Published: 5/13/2016   |   Inventor(s): Qing Xiao Li, Zhibin Liang
Keywords(s):  
Category(s): Healthcare, Biology, Therapeutic
anti-HMGB1 antibody for mesothelioma
In the US, asbestos causes approximately 2,000 - 3,000 malignant mesothelioma deaths per year, and it contributes to an even larger number of lung carcinomas. The latency from time of exposure to tumor development potentially allows time for intervention to block the mechanism(s) that trigger asbestos-induced carcinogenesis. This invention proposes...
Published: 5/29/2015   |   Inventor(s): Haining Yang, Michele Carbone, Marco Bianchi
Keywords(s):  
Category(s): Healthcare, Therapeutic
Mesothelioma Biomarker
Malignant mesothelioma, which is associated with asbestos or erionite exposure, is an aggressive and lethal cancer of the mesothelium, the protective lining that covers many internal organs and is most commonly found in the lungs. The inventors have discovered that misregulation of a protein called High Mobility Group Box 1 (HMGB1) is linked to mes...
Published: 5/29/2015   |   Inventor(s): Haining Yang, Michele Carbone, Harvey Pass
Keywords(s): Diagnostic:Marker, Healthcare:Diagnostic Tool, Healthcare:Oncology, Screening:Detection
Category(s): Healthcare, Diagnostic, Diagnostic, Therapeutic
Natural product inhibitors of Stat3 and NF-kappaB
Physalis peruviana and poha berry fruit have been found to control human cancer growth by blocking the abnormal functions of Stat3 and NF-kappaB signaling pathways. Inhibitory effects were observed in human glioma, bladder carcinoma, and breast cancer cells in vitro. ApplicationsGrowth inhibition in cancers with activated Stat3 and NF-kappaB signal...
Published: 5/26/2015   |   Inventor(s): Leng Chee Chang, John Pezzuto, James Turkson, Mayuramas Sang-Ngern
Keywords(s):  
Category(s): Healthcare, Therapeutic
A novel Stat3 inhibitor that suppresses growth, viability, survival and migration of human breast and glioma cells in vitro
Researchers have discovered a new chemical compound that blocks the cancer causing biological molecule called Stat3, and by doing so controls growth and existence of human cancer cells. The compound strongly inhibits the activated form of Stat3, and consequently attenuates Stat3 functions in cancer cells. Accordingly, treatment of human breast canc...
Published: 4/10/2013   |   Inventor(s): James Turkson, Patrick Gunning, Sina Haftchenary
Keywords(s): Healthcare:Oncology
Category(s): Healthcare, Therapeutic
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